SOCS1 抗体
Quick Overview for SOCS1 抗体 (ABIN6571338)
抗原
See all SOCS1 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Affinity purification
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免疫原
- Recombinant Protein of human SOCS1
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
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别名
- SOCS1
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背景
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Synonyms: CISH 1,CISH1,Cytokine inducible SH2 protein 1,JAB,JAK binding protein,JAK-binding protein,Janus kinase binding protein,SOCS 1,SOCS-1,Socs1,SOCS1,SSI 1,SSI-1,SSI1,STAT induced STAT inhibitor 1,STAT-induced STAT inhibitor 1,Suppressor of cytokine signaling 1,Supressor of cytokine signalling 1,TEC interacting protein 3,Tec-interacting protein 3,TIP 3,TIP-3,TIP3
Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
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分子量
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Observed_MW: 24kDa
Calculated_MW: 23kDa
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基因ID
- 8651
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UniProt
- O15524
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途径
- JAK/STAT Signaling, Interferon-gamma Pathway, TLR signaling, Response to Growth Hormone Stimulus
抗原
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